| Name of the Candidate Ms. Mona Vishwakarma (Roll No. 19041014) | |
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Exam Type Ph.D. pre-thesis submission seminar
Exam Date & Time
23-Dec-24 11:30 AM | |
| Topic Estimation of the Energy Barrier for Micelle-mediated Nucleation Growth on Surfaces: Strategic Reduction & its Application in Drug Delivery | |
| Message Dear Colleague, Mona Vishwakarma, Research scholar (19041014), will be delivering her Pre-PhD Seminar as per the schedule given below. Please find the details of her talk below. All DPGC members of the Department, RPEC members of the candidate, faculty members, research scholars and students are cordially invited to attend the seminar. With best regards, Debdip —— —— Title: Estimation of the Energy Barrier for Micelle-mediated Nucleation Growth on Surfaces: Strategic Reduction & its Application in Drug Delivery Speaker: Mona Vishwakarma, Research Scholar, Roll no. - 19041014, Department of Chemical Engineering & Technology, IIT (BHU) Varanasi Date: 23/12/2024 Time: 11:30 AM Venue: LT-7, Chemical Engineering & Technology Abstract Polyelemental nanoparticles are one of the most fascinating materials that offer multi-functionality. Often, the synthesis processes are highly energy-demanding. A solution-based process to synthesize it would be highly desired to reduce the energy demand. Understanding the nucleation of metals and their arrest in the solution phase is extremely important. We have used micelles to arrest the growth of the nano-clusters and investigated their subsequent voyage to a surface. We estimated the energy landscape of gold nucleate on another gold surface within a spherical micelle of cetyltrimethylammonium bromide (CTAB) in aqueous solutions using molecular dynamics simulations. There exists an energy barrier, and we estimated it using Umbrella Sampling. To reduce this energy requirement, we introduced Oleylamine (OLA) as a co-surfactant alongside CTAB. Micelle deformation, influenced by OLA, facilitated nucleate release onto the surface, though a significant energy barrier persisted. To address this, we introduced octane thiol molecules on the gold surface and micelles, which led to a steep decrease in the energy barrier. Subsequently, the optimum surface concentration of alkyl thiols was obtained. Additionally, we delve into the release of methotrexate from chitosan-based matrices that highlighted the effect of different solvent conditions and cross-linker concentrations on the release process. — Dr Debdip Bhandary | Assistant Professor | Chemical Eng. & Tech., IIT (BHU) Varanasi |  +91 542 716 5185 | |
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Name of the SupervisorDr Debdip Bhandary (supervisor)
Designation Assistant Professor (Chemical Engineering)
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| Mode of Exam offline Venue / Url : LT-7, Chemical Engineering & Technology | |
| Uploaded date 19-Dec-24 | |